Ribonuclease 5/Angiogenin Suppresses Intestinal Tumor Initiation by Maintaining Crypt Homeostasis - PubMed
4 hours ago
- #tRNA fragments
- #Colorectal Cancer
- #RNase5
- RNase5 (angiogenin) suppresses intestinal tumor initiation, contrary to its pro-tumorigenic role in established cancers.
- Mechanistically, cytoplasmic RNase5 restricts protein synthesis by producing stress-induced tRNA fragments (tiRNAs), maintaining intestinal homeostasis and preventing hyperproliferation.
- Exogenous RNase5 or RNase5-generated tiRNAs reduced adenoma number and size during tumorigenesis onset.
- Baseline serum RNase5 levels were inversely correlated with colorectal cancer (CRC) development in case-control studies.
- Findings suggest RNase5 as a key regulator in intestinal cell malignant transformation and a potential target for CRC prevention.