Microenvironment-Adaptive Smart Hydrogel with 2D Vanadium Nitride MXenzyme Rescues Osteoarthritis via Coordinated ROS Scavenging and Hspa5/GPX4 Axis-Mediated Ferroptosis Suppression - PubMed
9 hours ago
- #ferroptosis
- #hydrogel
- #osteoarthritis
- A microenvironment-adaptive hydrogel system (V2N MXenzyme@Gel) is developed to treat osteoarthritis (OA).
- The hydrogel features a dual-crosslinked network balancing mechanical robustness and flexibility.
- V2N MXenzyme mimics superoxide dismutase (SOD) and catalase (CAT) activities, neutralizing ROS into water and oxygen while generating nitric oxide (NO).
- The system alleviates oxidative damage and suppresses ferroptosis by regulating the Hspa5/GPX4 axis.
- Intra-articular administration of V2N MXenzyme@Gel reduces cartilage degradation and inflammation in OA rats.
- The hydrogel restores metabolic homeostasis of chondrocyte extracellular matrix (ECM).
- The study proposes a novel precision strategy for managing chronic joint diseases.