Interaction between transient receptor potential vanilloid 4 and glutamate NMDA receptor subunit 1 mediates endoplasmic reticulum stress and neuroinflammation in postoperative delirium - PubMed
4 days ago
- #Neuroinflammation
- #TRPV4-GluN1 axis
- #Postoperative delirium
- Postoperative delirium (POD) is a serious neurocognitive complication with unclear mechanisms.
- Study identifies a pathogenic pathway involving TRPV4 and GluN1 interaction in POD.
- TRPV4-GluN1 coupling promotes GluN1 phosphorylation and hyperactivates NMDAR signaling.
- Results show induction of ER stress and neuroinflammation in the hippocampus.
- Pharmacological inhibition of TRPV4 or hippocampal Trpv4 knockdown reverses pathologies.
- TRPV4 upregulation also observed in early-onset Alzheimer's disease patients.
- TRPV4-GluN1 axis is a promising therapeutic target for POD.