RETREG1/FAM134B-mediated ERGICphagy regulates GSDME-dependent dendritic cell pyroptosis during sepsis - PubMed
5 days ago
- #sepsis
- #autophagy
- #pyroptosis
- RETREG1/FAM134B-mediated ERGICphagy plays a crucial role in regulating GSDME-dependent dendritic cell pyroptosis during sepsis.
- Upregulation of RETREG1 is associated with maintaining immune function in sepsis, while its depletion aggravates DC pyroptosis and immune dysfunction via the CASP3-GSDME pathway.
- Defective RETREG1 expression inhibits ERGIC autophagy, leading to abnormal STING1 activation and subsequent CASP3-GSDME-dependent pyroptosis.
- Downregulation of Tmed9 prevents STING1 activation and GSDME-mediated pyroptosis by disrupting ERGIC structure.
- Modulating RETREG1 genetically or pharmacologically could be a therapeutic strategy for sepsis-induced immune suppression.