Summary of WHO clinical practice guidelines for influenza - PubMed
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- #WHO guidelines
- #influenza
- WHO clinical practice guidelines for influenza were updated on 12 September 2024.
- Guidelines focus on patient-centered benefits and harms, considering resource implications, feasibility, equity, and human rights.
- 29 recommendations were made, including 21 on antiviral medications and 6 on adjunctive therapies.
- For seasonal influenza, WHO conditionally recommends oseltamivir for severe illness and baloxavir for high-risk patients within 48 hours of symptom onset.
- Prophylaxis is conditionally recommended for those exposed to zoonotic influenza and high-risk individuals exposed to seasonal influenza.
- Strong recommendation against antibiotics for non-severe influenza and conditional recommendation against corticosteroids, macrolides, mTOR inhibitors, NSAIDs, and passive immune therapy for severe influenza.
- Diagnostic testing strategies are recommended for both non-severe and severe influenza.
- Evidence is based on four systematic reviews of RCTs with low to very low certainty.
- No significant conflicts of interest were reported among the guideline panel members.