Causal links among gut microbiota, immune-inflammatory and compensatory immune-regulatory systems, and schizophrenia - PubMed
4 hours ago
- #Immune Systems
- #Gut Microbiota
- #Schizophrenia
- Mendelian randomization study using GWAS data identifies causal links between gut microbiota, immune systems, and schizophrenia.
- Protective causal effects found for gut microbiota genera Barnesiella, Desulfovibrio, Gordonibacter, and Romboutsia (OR = 0.85-0.93).
- Risk effect identified for gut microbiota Clostridium innocuum (OR = 1.09).
- Immune trait tumor necrosis factor receptor 1 (sTNF-R1) shows protective effect (OR = 0.83).
- Regulatory T cell (Treg) counts increase schizophrenia risk (OR = 1.05).
- Multivariate MR confirms independent effects of Desulfovibrio, Gordonibacter, and sTNF-R1.
- Findings suggest specific gut microbiota and immune traits independently contribute to schizophrenia pathogenesis.
- Tregs highlighted as a potential therapeutic target for psychosis.