Hemolysis After Pulsed Field Ablation With a Variable-Loop Irrigated Circular Catheter - PubMed
4 hours ago
- #Pulsed Field Ablation
- #Atrial Fibrillation
- #Hemolysis
- Hemolysis is a known complication of endocardial pulsed field ablation (PFA), influenced by factors like number of applications, tissue contact, and PFA system characteristics.
- Study evaluated hemolysis in seven patients with paroxysmal atrial fibrillation using a variable-loop irrigated circular catheter (VLCC) and TRUPULSE generator.
- Significant increase in plasma-free hemoglobin levels post-procedure (from 0.01 to 0.05 g/dL, p < 0.001).
- Post-procedural reductions in hemoglobin and increases in bilirubin and lactate dehydrogenase levels observed, with subnormal haptoglobin in 50% of patients.
- Creatine kinase levels increased significantly postoperatively (from 84 to 323 U/L, p = 0.018).
- No acute kidney injury cases; renal function remained stable post-procedure.
- First study to evaluate hemolysis with VLCC-based PFA using plasma-free hemoglobin as a biomarker.
- Findings highlight the need to evaluate each PFA system individually for safety and biophysical effects.