Usefulness of plasma bile acid profile as a prognostic biomarker for drug-induced liver injury - PubMed
3 hours ago
- #bile acids
- #prognostic biomarker
- #drug-induced liver injury
- Plasma bile acid (BA) levels are elevated in drug-induced liver injury (DILI) patients and those with nonDILI causes.
- Higher levels of total, primary, and conjugated BAs at diagnosis are linked to a higher likelihood of DILI progression in severity.
- Specific BA ratios, such as primary-to-secondary BAs and (cholic acid + deoxycholic acid) to (chenodeoxycholic acid + lithocholic acid), enhance the prognostic value of the MELD score.
- BA profiling may aid in early identification of severe DILI cases and outcomes like death or liver transplantation.
- Validation in an independent longitudinal study is required to confirm BA profiling as a prognostic biomarker for DILI.