CRLF2-rearrangement and Extramedullary Disease in B-cell Acute Lymphoblastic Leukemia: A Possible Link? - PubMed
2 days ago
- #Extramedullary disease
- #CRLF2-rearrangement
- #B-cell acute lymphoblastic leukemia
- CRLF2-rearrangement (CRLF2r) is a poor prognostic marker in B-cell acute lymphoblastic leukemia (B-ALL) and confers chemotherapeutic resistance.
- Extramedullary disease (EMD), including CNS and non-CNS involvement, is associated with worse outcomes in B-ALL.
- A retrospective study found that 90.5% of relapsed/refractory CRLF2r B-ALL patients had EMD, compared to 50% in non-CRLF2r patients.
- Among CRLF2r patients, 38.1% presented with EMD at diagnosis, and 80.9% had EMD at relapse.
- The study suggests a potential link between CRLF2r and EMD in relapsed/refractory B-ALL, warranting further investigation.