Activation of GPR35 in the Anterior Cingulate Cortex Alleviates Neuropathic Pain and Depression-Related Behavior - PubMed
4 hours ago
- #GPR35
- #neuropathic pain
- #anterior cingulate cortex
- GPR35 activation in the anterior cingulate cortex alleviates neuropathic pain and depression behaviors in mice, identifying it as a therapeutic target.
- Patients with neuropathic pain show elevated GPR35 levels, correlating with pain intensity, and mice studies confirm GPR35's role in pain and emotional disturbances.
- GPR35's effects are mediated through Nr4a1-dependent PI3K/AKT pathway activation, reducing neuroinflammation and improving affective behaviors.
- Treatment with GPR35 agonist L-Kyna in mice reduces pain hypersensitivity and depression-related behaviors, supporting its pharmacological potential.