The Adiponectin-PP2A Pathway Confers Cognitive Benefits of Physical Exercise Against Chronic Stress-Induced Tau Hyperphosphorylation in the Hippocampus - PubMed
4 hours ago
- #Alzheimer's disease
- #Tau phosphorylation
- #Exercise benefits
- The study explores the Adiponectin-PP2A pathway's role in mitigating Tau hyperphosphorylation in Alzheimer's disease (AD) through physical exercise.
- Exercise increases adiponectin levels, which activates PP2A, reducing Tau hyperphosphorylation and enhancing hippocampal plasticity.
- Adiponectin knockout (Adipo-/-) and hippocampal-specific PP2A knockdown (PP2A-KD) mice models were used to assess the effects of exercise and chronic stress.
- Running improved cognitive deficits and reduced Tau hyperphosphorylation in stressed mice by increasing adiponectin levels and PP2A activity.
- Adiponectin deficiency impaired cognitive performance, increased Tau phosphorylation, and decreased PP2A activity.
- PP2A knockdown diminished the benefits of running, indicating PP2A is downstream of adiponectin's action.
- The study suggests the adiponectin-PP2A pathway as a potential therapeutic target for AD.