Efficacy of radiotherapy to metastatic lesion in de novo metastatic nasopharyngeal carcinoma patients: A multicenter, propensity score matching study - PubMed
5 hours ago
- #Metastatic Lesion Radiotherapy
- #Nasopharyngeal Carcinoma
- #Overall Survival
- Study investigates efficacy of metastatic lesion radiotherapy (MLRT) in de novo metastatic nasopharyngeal carcinoma (dmNPC) patients.
- Multicenter study with 1,503 patients; after propensity score matching, 122 received MLRT, 366 did not.
- MLRT group showed significantly better overall survival (OS) (3-year OS: 79.0% vs. 65.8%).
- MLRT identified as independent favorable predictor of OS (hazard ratio: 0.64).
- Subgroup analyses show MLRT benefits patients with bone metastases, oligo-metastases, ≤5 metastatic lesions, and undetectable EBV DNA post-2-6 cycles.
- Higher radiation doses (BED >72 Gy, EQD2 >60 Gy) linked to improved OS.
- Conclusion: MLRT offers survival benefits, especially for limited metastatic burden, with higher doses providing greater benefits.