Cordyceps cicadae polysaccharides ameliorate ulcerative colitis by modulating the gut microbiota and regulating the bile acid/FXR/NF-κB signaling pathway - PubMed
3 hours ago
- #ulcerative-colitis
- #bile-acid-metabolism
- #gut-microbiota
- Cordyceps cicadae polysaccharides (CCP) show therapeutic potential for ulcerative colitis (UC) by modulating gut microbiota and bile acid metabolism.
- CCP treatment in a DSS-induced colitis mouse model improved symptoms like weight loss, colon length preservation, and reduced histopathological damage.
- 16S rDNA sequencing showed CCP restored gut microbial diversity, notably increasing Clostridium Kas107-2 (cluster XIVa).
- Metabolomics revealed CCP normalized bile acid metabolism, increasing secondary bile acids (deoxycholic acid, lithocholic acid) and reducing primary bile acids (α/β-MCA).
- CCP activated FXR signaling, suppressed NF-κB pathway, and reduced pro-inflammatory cytokines (TNF-α, IL-1β, IL-6).
- Fecal microbiota transplantation (FMT) from CCP-treated mice replicated protective effects, confirming microbiota-mediated mechanisms.
- CCP enhances intestinal barrier integrity by upregulating tight junction proteins (ZO-1, Occludin, Claudin-1).