Identification of distinct and shared biomarker panels in different manifestations of cerebral small-vessel disease through proteomic profiling - PubMed
4 hours ago
- #cerebral small-vessel disease
- #proteomics
- #biomarkers
- Proteomic profiling identified distinct and shared biomarker panels in cerebral small-vessel disease (cSVD) manifestations.
- Common markers across cSVD include extracellular matrix dysregulation and vascular remodeling proteins like ELN, POSTN, CCN2, and MMP12.
- These biomarkers were validated in cerebrospinal fluid and some predicted future cerebrovascular events better than current clinical risk scores.
- Microglial-associated proteins were linked to faster white matter lesion (WML) progression, while neuron-derived proteins mediated WML-related cognitive decline.
- The study provides a comprehensive biomarker atlas for cSVD, offering potential for improved diagnostics and therapeutics.