ALDH1A1 is a potential novel target for treatment of ADPKD - PubMed
4 hours ago
- #disulfiram
- #ADPKD
- #ALDH1A1
- ALDH1A1 identified as a novel risk factor for ADPKD.
- ALDH1A1 activates proliferative pathways and acts as a transcription factor.
- Disulfiram targeting ALDH1A1 delays cyst growth in ADPKD mice.
- Combination of low-dose disulfiram and anti-PD-L1 antibody shows synergistic effects in attenuating cyst progression.
- ALDH1A1 upregulation noted in other kidney diseases, requiring further study.
- Repurposing ALDH1A1 inhibitors and PD-L1 blockades suggested as a novel ADPKD therapy.