PE_PGRS23 promotes intracellular survival of Mycobacterium tuberculosis by competitively regulating autophagy gene expression through TFEB and USF2 - PubMed
3 hours ago
- #Mycobacterium tuberculosis
- #Autophagy
- #Immune evasion
- PE_PGRS23 protein of Mycobacterium tuberculosis (Mtb) enhances intracellular survival by inhibiting autophagy in macrophages.
- PE_PGRS23 facilitates nuclear translocation of TFEB via PI3K-AKT-mTOR-mediated dephosphorylation and promotes USF2 nuclear translocation.
- PE_PGRS23 causes TFEB and USF2 to compete for binding at the MAPLC3 promoter, suppressing MAPLC3 transcription and autophagy.
- In vivo studies show PE_PGRS23 increases Mtb survival and worsens lung tissue damage.
- The study highlights PE_PGRS23's role in immune evasion by inhibiting autophagy through TFEB and USF2 regulation.