Inverse Association Between Triglyceride-Glucose Index and Ischemic Stroke in Hospitalized Patients with Chronic Obstructive Pulmonary Disease and Atrial Fibrillation: A Retrospective Analysis - PubMe
4 hours ago
- #ischemic stroke
- #COPD
- #atrial fibrillation
- Study investigates the triglyceride-glucose (TyG) index as a metabolic marker for ischemic stroke (IS) risk in hospitalized patients with chronic obstructive pulmonary disease (COPD) and atrial fibrillation (AF).
- Retrospective analysis of 710 patients (2014-2024) found an inverse association between higher TyG index and lower IS risk, contrary to findings in the general population.
- Multivariate logistic regression showed each unit increase in TyG index was associated with lower IS risk (aOR=0.24, 95% CI:0.10-0.57, P=0.001), though results should be interpreted cautiously due to limited events (n=32).
- Generalized additive models (GAM) confirmed a linear inverse relationship after adjusting for stroke history (OR=0.50, 95% CI:0.30-0.90, P=0.032).
- The TyG index predicted IS with an AUC of 0.614 (95% CI:0.513-0.715), suggesting potential as a biomarker but requiring further validation.
- Possible explanations for the inverse association include a true metabolic paradox or reverse causality (low TyG indicating disease severity, malnutrition, or chronic inflammation).
- Limitations include lack of comprehensive disease severity and nutritional assessments, necessitating population-based studies to address selection bias.