FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3 - PubMed
5 hours ago
- #IDD
- #FGF21
- #Mitophagy
- FGF21 downregulation is linked to Intervertebral Disc Degeneration (IDD) and NPCs senescence.
- FGF21 upregulates SIRT1, promoting FOXO3 deacetylation, enhancing mitophagy, and reducing NPCs senescence.
- In vivo, FGF21 treatment improves disc height and histological scores in IDD models.
- The FGF21/SIRT1/FOXO3/PINK1/Parkin axis is a potential therapeutic target for IDD.