Anti-gout active ingredients from natural plant medicines and their related mechanisms - PubMed
5 days ago
- #Natural Products
- #Gouty Arthritis
- #Traditional Chinese Medicine
- Gout has been historically documented in both Western and Chinese medical texts, referred to as the 'disease of kings' and 'bi syndrome' respectively.
- Natural plant medicines and remedies like colchicine have been traditionally used for gout treatment.
- Gouty arthritis (GA) necessitates long-term treatment, highlighting the need for safe and effective natural products.
- This review is the first to comprehensively analyze plant extracts and monomeric compounds for GA treatment, focusing on their mechanisms.
- 282 studies identified 164 plant extracts and 148 bioactive compounds with anti-gout properties.
- Key active components include terpenoids, polyphenols, and flavonoids, with mechanisms like uric acid reduction, anti-inflammatory, and antioxidant effects.
- Notable compounds such as ginsenosides and anemoside B4 show multi-target pharmacological effects.
- The study provides a foundation for developing multi-target GA therapies and identifies promising compounds for further research.