Three-dimensional patient-derived endometriosis model for drug evaluation - PubMed
4 hours ago
- #3D model
- #drug evaluation
- #endometriosis
- Developed a 3D patient-derived endometriosis model combining epithelial organoids and stromal cells to study disease mechanisms and drug responses.
- Successfully cultured patient-derived epithelial gland-like organoids and stromal cells, showing high consistency with native endometriotic lesions.
- Identified key biological markers (ERs, PRs, E-cadherin, CD44, ICAM1, ITGB3, CK7, MMP2/9, TIMP1, TIMP2) in the models.
- Observed heterogeneous drug responses to dienogest, highlighting potential interpatient variability in treatment outcomes.
- Proposed the model as a valuable platform for investigating endometriosis and screening potential therapeutic agents.