Colorectal Cancer Risk With Negative Colonoscopy or Nonadherence After Positive FOBT Screening - PubMed
4 hours ago
- #screening
- #colonoscopy
- #colorectal cancer
- Population-based colorectal cancer (CRC) screening programs are implemented globally, with variations in CRC risk by colonoscopy outcome.
- The study evaluated CRC incidence after a negative screening colonoscopy or nonadherence to colonoscopy in individuals with a positive fecal occult blood test (FOBT).
- Conducted in Stockholm-Gotland, Sweden, from 2008 to 2021, the study included 318,096 individuals invited to CRC screening, with 14,873 having a positive FOBT result.
- Individuals with a negative colonoscopy result had a significantly lower CRC incidence (SIR, 0.52) compared to the general population, with men showing a greater decrease (SIR, 0.37) than women (SIR, 0.71).
- Nonadherence to follow-up colonoscopy after a positive FOBT resulted in a markedly increased CRC incidence (SIR, 4.21).
- The findings support risk-based, individualized follow-up strategies and highlight the need for targeted interventions in nonadherent individuals to improve early CRC detection.