Tubular La Ribonucleoprotein 7 Suppresses TGF-β/SMAD3 Signaling and Attenuates Kidney Fibrogenesis - PubMed
7 hours ago
- #LARP7
- #TGF-β Signaling
- #Kidney Fibrosis
- LARP7 is downregulated in chronic kidney disease (CKD) patients and inversely correlated with TGF-β/SMAD3 activation.
- LARP7 inhibits SMAD3 linker phosphorylation by sequestering CDK9, disrupting TGF-β/SMAD3 signaling.
- TGF-β1 suppresses LARP7 expression, creating a self-reinforcing feedback loop that promotes fibrosis.
- Tubule-specific Larp7 deletion worsens kidney fibrosis, while its overexpression attenuates fibrotic progression in various models.