Conditional Modeling of GNAO1 Disorder Dissociates Circuit Specific Contributions to Pathology and Rationalizes Ameliorative Strategies - PubMed
3 hours ago
- #circuit-specific pathology
- #GNAO1 disorder
- #neurodevelopmental disorders
- A conditional knock-in mouse model of the GNAO1 G203R variant enables circuit-specific induction of the mutation.
- Circuit-specific contributions of Gαo dysfunction to motor and epileptic manifestations were identified in striatal and forebrain neurons.
- Region-specific molecular profiles and synaptic transmission impacts were established, guiding therapeutic strategies.
- Caffeine intervention effectively rescued motor abnormalities in the model.
- Findings emphasize Gαo's role in neural circuit homeostasis and support circuit-based therapies for GNAO1 disorder.