Ovarian Matrisome Dynamics and αvβ3-Mediated Regulation in Early Follicular Development - PubMed
3 hours ago
- #matrisome
- #integrin αvβ3
- #early follicular development
- Early follicular development (EFD) is crucial for ovarian function, involving growth from primordial to small antral stages.
- Integrated transcriptomic and proteomic analyses reveal matrisome dynamics during EFD in prepubertal mouse ovaries.
- Cross-species comparison shows matrisome-associated enrichment in mice, sheep, and pigs.
- Instrumental nanoindentation and Raman spectroscopy provide mechanical, topographical, and biochemical data.
- Integrin αvβ3 is identified as a critical receptor mediating matrisome signals to follicles.
- Inhibition of αvβ3 promotes primordial follicle activation but induces follicular atresia.
- Disruption of matrisome signals hinders secondary follicle growth and oocyte maturation.
- Human ovarian tissues show similar collagen remodeling and stage-specific αvβ3 expression.
- The study offers insights into ovarian dysfunction and impaired follicular development.