IV Tenecteplase Before Thrombectomy Compared With Thrombectomy Alone in Patients With Stroke Due to a Large Vessel Occlusion - PubMed
8 days ago
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- #stroke
- #thrombectomy
- IV tenecteplase before thrombectomy (TNK + EVT) improves 3-month functional outcomes compared to thrombectomy alone (EVT) in large vessel occlusion stroke patients.
- The study analyzed 1,890 patients (798 TNK + EVT, 1,092 EVT) with anterior circulation large vessel occlusion within 4.5 hours of symptom onset.
- TNK + EVT showed better outcomes on the modified Rankin Scale (mRS) and functional independence (OR 1.50, p < 0.001), with no significant safety concerns.
- The benefit of TNK + EVT was consistent regardless of whether patients were first admitted to primary or comprehensive stroke centers.
- No significant time dependency was observed for the efficacy of TNK + EVT (p-interaction = 0.11).
- No differences in parenchymal hematoma or symptomatic intracerebral hemorrhage rates were found between the two treatment groups.
- The findings support the routine use of tenecteplase before EVT in the early treatment window for large vessel occlusion stroke.