Molecular and cellular bases of trained immunity - PubMed
4 hours ago
- #epigenetic remodeling
- #innate immunity
- #trained immunity
- Trained immunity is the long-lasting functional adaptation of innate immune cells, such as monocytes, tissue-resident macrophages, and hematopoietic stem and progenitor cells, after transient stimulation.
- This process is driven by coordinated epigenetic and metabolic changes that enhance subsequent inflammatory responses.
- A unifying framework proposes that metabolic and epigenetic remodeling initiates trained states, but durable maintenance relies on persisting factors like transcription factor activity and environmental signals.
- Understanding the encoding, preservation, and regulation of trained immunity is crucial for leveraging its potential in infection, inflammation, and immunotherapy.