Gut Microbiota Dysbiosis Promotes CKD-associated Atrial Fibrillation Through Activation of the NLRP3 Inflammasome - PubMed
3 hours ago
- #Atrial Fibrillation
- #Gut Microbiota
- #Chronic Kidney Disease
- Chronic kidney disease (CKD) increases the risk of atrial fibrillation (AF).
- Gut microbiota dysbiosis in CKD is linked to heightened AF susceptibility.
- Fecal microbiota transplantation (FMT) from CKD rats transferred AF susceptibility to healthy rats.
- Activation of the NLRP3 inflammasome is a key mechanism in CKD-associated AF.
- Elevated indoxyl sulfate (IS) and lipopolysaccharide (LPS) levels contribute to AF pathogenesis.
- Treatment with AST-120 or gut barrier protectants prevented CKD-associated AF.
- Supplementation with Lactobacillus gasseri reduced AF susceptibility in CKD rats.
- Modulating gut microbiota could be a new therapeutic strategy for CKD-associated AF.