Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple-Negative Breast Cancer by Disrupting the Hippo-YAP/TEAD4-PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation - PubMed
5 hours ago
- #endoplasmic reticulum stress
- #natural product therapy
- #triple-negative breast cancer
- Tetrastigma Hemsleyanum Polysaccharide (THP) suppresses triple-negative breast cancer (TNBC) by disrupting the Hippo-YAP/TEAD4-PDIA4 axis.
- THP activates the Hippo kinase cascade, leading to YAP phosphorylation and degradation, which attenuates TEAD4 activity and downregulates PDIA4 expression.
- This disruption causes catastrophic ER stress in TNBC cells, inhibiting migration, invasion, angiogenesis, and metastasis in preclinical models without toxicity.