Low PTGDS Expression Facilitates HNSCC by Suppressing Programmed Cell Death and Reducing B Cell-Mediated Immune Responses - PubMed
4 hours ago
- #immunotherapy
- #PTGDS
- #HNSCC
- Low PTGDS expression is linked to HNSCC progression by suppressing programmed cell death (PCD) and reducing B cell-mediated immune responses.
- Cancer-associated fibroblasts (CAFs) in the HNSCC tumor microenvironment (TME) contribute to PCD resistance, but the mechanism was unclear.
- Study utilized single-cell sequencing, TCGA data, and spatial transcriptome analysis to identify seven CAF subsets and their differentiation paths.
- PTGDS and SQLE were identified as key prognostic genes among 32 CAF-associated PCD regulators.
- PTGDS is downregulated in HNSCC and associated with better prognosis; its overexpression inhibits cancer cell proliferation and invasion while promoting apoptosis.
- PTGDS enhances B cell-related immune responses by increasing CXCL13 expression and immune cell infiltration.
- Findings suggest PTGDS as a potential diagnostic biomarker and therapeutic target in HNSCC.