Structural basis for DNA processing and membrane translocation by ComEC in natural transformation - PubMed
3 hours ago
- #ComEC
- #DNA translocation
- #Natural transformation
- ComEC is a membrane protein essential for DNA translocation during natural transformation in bacteria.
- Cryo-EM structures show ComEC in DNA-free, ssDNA-bound, and dsDNA-bound states.
- ComEC cleaves one strand of dsDNA at the extracellular domain and guides the remaining strand through a positively charged pore in the membrane.
- These findings explain ComEC's roles in both DNA processing and translocation across the inner membrane.