ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: A human and experimental study - PubMed
3 hours ago
- #multiple sclerosis
- #polyamines
- #B cells
- Meningeal inflammation in multiple sclerosis (MS) is linked to worse clinical outcomes.
- Ectopic lymphoid follicles with B cells are found in meninges of MS patients and EAE models.
- Metabolites of the arginine/polyamine pathway correlate with meningeal inflammation in MS and EAE.
- Ornithine Decarboxylase (ODC1) and polyamine metabolism are reduced in meningeal B cells in EAE.
- ODC1 inhibition restricts meningeal T cells but promotes B cell proliferation.
- B cell-specific ODC1 deletion leads to age-associated B cell-like phenotype and exacerbates EAE.
- Polyamines have divergent roles in regulating B and T cell responses in meningeal autoimmunity.