Portulaca oleracea L. polysaccharide alleviates colitis-associated bone loss through Muribaculaceae-enriched gut microbiota and elevated colonic melatonin - PubMed
4 hours ago
- #Bone Health
- #Gut Microbiota
- #Colitis
- Portulaca oleracea L. polysaccharide (POP) alleviates colitis and bone loss in a mouse model by enriching Muribaculaceae in the gut microbiota.
- Transplanting POP-modulated microbiota replicates therapeutic effects, which are maintained with gentamicin but abolished by vancomycin, linking Muribaculaceae to benefits.
- POP increases colonic melatonin levels via microbiota changes, and exogenous melatonin similarly reduces colitis and bone loss, while its inhibitor 4P-PDOT blocks protection.