Structural basis of lipid-linked galactan export by the mycobacterial ABC transporter Wzm-Wzt - PubMed
4 hours ago
- #Mycobacteria
- #ABC transporter
- #Cell wall biosynthesis
- The study investigates the structural basis of lipid-linked galactan (LLG) export by the mycobacterial ABC transporter Wzm-Wzt.
- Cryo-EM structures of Wzm-Wzt from Mycobacterium abscessus reveal different conformations during the transport cycle.
- A cytosolic gate helix (GH) is identified as crucial for polysaccharide transport.
- The proposed mechanism involves the hydrophobic polyprenyl-moiety being translocated first, followed by the galactan-polysaccharide.
- The findings could aid in developing drugs targeting mycobacterial cell wall biosynthesis.