Deltex E3 ubiquitin ligase 2 prevents sepsis-induced myocardial injury through degrading TfR1 via promoting K27-linked ubiquitination - PubMed
4 hours ago
- #sepsis
- #myocardial injury
- #ubiquitination
- DTX2 expression is upregulated in sepsis-induced myocardial injury.
- DTX2 deficiency worsens myocardial hypertrophy, fibrosis, ferroptosis, and mitochondrial dysfunction in sepsis.
- Cardiac-specific overexpression of DTX2 improves cardiac function in septic cardiomyopathy.
- DTX2 interacts with TfR1, promoting K27-linked ubiquitination and degradation of TfR1, regulating iron metabolism.
- Pharmacological inhibition of ferroptosis counteracts the negative effects of DTX2 deficiency.
- Silencing TfR1 reduces ferroptosis and myocardial injury in DTX2 knockout septic mice.
- DTX2 protects against abnormal iron accumulation and ferroptosis in sepsis-induced myocardial injury.