Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages - PubMed
3 hours ago
- #NLRP3 inflammasome
- #osteoporosis
- #macrophage senescence
- Skeletal aging involves increased fragility, reduced bone mass, and deterioration of bone microstructure.
- Macrophage senescence contributes to skeletal aging, with decreased Sirtuin3 (Sirt3) expression leading to increased NLRP3 inflammasome activation.
- Sirt3-enriched apoptotic bodies (ABs-Sirt3) were developed to target macrophages, promoting NLRP3 degradation and delaying skeletal aging.
- The study highlights a nanotechnology-based therapeutic approach for age-related osteoporosis by targeting immune senescence.