ACSL4 in Alzheimer's disease: Pathogenetic mechanisms and potential therapeutic targets - PubMed
3 hours ago
- #ACSL4
- #Ferroptosis
- #Alzheimer's Disease
- Iron metabolism dysregulation is involved in Alzheimer's disease (AD).
- Ferroptosis, an iron-dependent cell death, is a key contributor to AD pathogenesis.
- ACSL4 enzyme enhances ferroptosis by incorporating oxidizable fatty acids into membranes.
- ACSL4 also plays roles in neuroinflammation and oxidative stress in AD progression.
- Targeting ACSL4 shows therapeutic promise for AD treatment.
- Natural and synthetic compounds targeting ACSL4 have potential in AD therapy.