miR-203 facilitates timely cell fate transitions via epigenetic modulation during early embryogenesis - PubMed
a day ago
- #miR-203
- #embryogenesis
- #epigenetics
- miR-203 regulates timely cell fate transitions during early embryogenesis via epigenetic modulation.
- Loss of miR-203 slows preimplantation development, increasing embryos with totipotency markers like MERVL.
- miR-203 targets histone acetylases, including EP300, to control cell specification in early embryos.
- The study uses genetically engineered mouse models and single-cell RNA sequencing for in vivo analysis.
- Findings suggest miR-203 fine-tunes EP300 levels to ensure correctly paced developmental transitions.