Androgen receptor expression and immune characteristics of HER2-low metastatic triple-negative breast cancer - PubMed
6 days ago
- #breast cancer
- #androgen receptor
- #HER2-low
- HER2-low expression is associated with hormone receptor (HR) expression in HR-positive breast cancer.
- Androgen receptor (AR) expression was significantly enriched in HER2-low metastatic triple-negative breast cancer (mTNBC) compared to HER2-0 mTNBC (mean: 33.7% vs. 21.4%, p = 0.038).
- No significant immunological differences were observed between HER2-low and HER2-0 mTNBC.
- HER2-low/AR-positive patients showed a trend towards longer overall survival, indicating potential biomarker relevance.
- Multiple authors report consulting fees, institutional research support, and other financial disclosures related to various pharmaceutical companies.