POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation - PubMed
3 days ago
- #chemoresistance
- #colorectal cancer
- #POU2F1
- POU2F1 is overexpressed in chemotherapy-resistant colorectal cancer (CRC) cells.
- POU2F1 promotes chemoresistance by suppressing MDR2 protein degradation.
- POU2F1 stimulates MCT4 expression, leading to cytosolic lactate export.
- Decreased PPP1R11 lactylation due to lactate export stabilizes MDR2.
- PPP1R11 lactylation normally promotes MDR2 ubiquitination and degradation, sensitizing cells to chemotherapy.
- The study links POU2F1 to chemoresistance and protein lactylation regulation in CRC.