Foot-and-mouth disease virus-like particle mRNA vaccine induces strong humoral and cellular immunity - PubMed
6 hours ago
- #mRNA vaccine
- #virus-like particle
- #foot-and-mouth disease
- A novel foot-and-mouth disease mRNA vaccine that self-assembles into virus-like particles (VLPs) was developed.
- The VLP mRNA vaccine induces strong humoral immunity with long-lasting antibody production and effectively activates cellular immunity.
- It provides protective efficacy comparable to traditional inactivated vaccines in guinea pig challenge models.
- The vaccine addresses limitations of conventional vaccines, such as short-term immune persistence and biosafety concerns.
- It offers an innovative approach for FMD control and a technical foundation for VLP mRNA vaccines against other animal diseases.