Glucagon-Like Peptide 1 Receptor Agonists and Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients With Type 2 Diabetes - PubMed
5 days ago
- #GLP-1 RAs
- #NAION
- #Type 2 Diabetes
- Study compares the risk of nonarteritic anterior ischemic optic neuropathy (NAION) between GLP-1 RA and DPP-4 inhibitor users in type 2 diabetes patients.
- GLP-1 RAs showed a higher 1-year risk of NAION compared to DPP-4 inhibitors (RR 2.56; 95% CI 1.44-4.86).
- Higher NAION risk was observed in the first 6 months of GLP-1 RA use, especially in younger patients, men, ever-smokers, and those with significant HbA1c reduction.
- The study utilized data from the U.K. Clinical Practice Research Datalink, employing propensity-score fine-stratification weighting for adjustments.