Metabolic alterations after traumatic neural injury: Mechanistic insights and potential translational targets for axon regeneration - PubMed
4 hours ago
- #axon-regeneration
- #neural-repair
- #metabolism
- Metabolism provides essential substances and energy for cells and influences gene expression to maintain homeostasis.
- Neuronal injury triggers metabolic changes in neurons and supporting cells, affecting survival and regeneration.
- Axon regeneration is crucial for neural repair and is influenced by systemic factors like diet, exercise, and stress.
- The review focuses on glycometabolism, lipid metabolism, protein degradation, mitochondrial activity, and systemic metabolic cross-talk.
- Metabolites have therapeutic potential, with distinct responses in peripheral and central nervous systems.
- Successful neural repair requires a systemic pro-regenerative state throughout the body.