Hepatocyte CEBPA-ORM1 axis restricts alcohol-associated liver disease - PubMed
3 days ago
- #CEBPA-ORM1 axis
- #Alcohol-associated liver disease
- #Hepatokine
- Hepatocyte CEBPA-ORM1 axis plays a critical role in restricting alcohol-associated liver disease (ALD).
- CEBPA expression decreases during ALD progression in human patients, and its knockout in mice exacerbates alcohol-associated steatosis.
- ORM1, identified as a top CEBPA-upregulated gene, is directly activated by CEBPA and its loss worsens ALD severity.
- Restoring CEBPA or ORM1 via AAV8 delivery or recombinant ORM1 protein reduces hepatic lipid accumulation and disease progression.
- Serum ORM1 inversely correlates with ALD severity, suggesting its potential as a biomarker for staging ALD.