Triglyceride-Glucose Index and Mortality Risk in the General Population: A Systematic Review and Meta-analysis of Prospective Studies - PubMed
5 hours ago
- #cardiovascular mortality
- #meta-analysis
- #TyG index
- The triglyceride-glucose (TyG) index is a simple and inexpensive surrogate marker for insulin resistance (IR).
- This study evaluates the TyG index's predictive value for all-cause and cardiovascular mortality in the general population.
- A systematic review and meta-analysis included 12 studies with 14 independent cohorts (over 10.8 million participants).
- Each one-unit increase in TyG was associated with a 14% higher risk of all-cause mortality and a 16% higher risk of cardiovascular mortality.
- The dose-response relationship was linear, starting from a TyG index of 6.9 units (or 3.79 in an alternative scale).
- The TyG index independently predicts mortality, supporting its use for early cardio-metabolic risk stratification.
- No evidence of publication bias was found, though significant heterogeneity among studies was noted.