Cumulative adverse childhood experiences increase migraine risk in later life in China: evidence from CHARLS with mediation and Mendelian randomization - PubMed
4 hours ago
- #Adverse Childhood Experiences
- #Migraine
- #Depression
- Cumulative Adverse Childhood Experiences (ACEs) significantly increase migraine risk in middle-aged/elderly Chinese individuals.
- Each additional ACE point raises migraine risk by 18%, with ≥4 ACEs nearly doubling the risk (HR = 1.99).
- Depressive symptoms mediate 21.5% of the ACEs-migraine link, highlighting a key psychological pathway.
- Mendelian randomization validates ACEs as a migraine risk factor (OR = 1.64) and confirms depression's mediating role (20.1%).
- Genetic correlation between ACEs and migraine is significant (LDSC Rg = 0.23, P < 0.001).
- Study uses CHARLS data (2011-2020) with 8,410 participants (≥45 years) and multivariable COX regression analysis.