Immune-metabolic positive feedback model in COPD: cross-mechanisms and potential intervention strategies - PubMed
4 hours ago
- #mitochondrial injury
- #COPD
- #immune-metabolic dysfunction
- COPD is a chronic condition with high disability and mortality rates, affecting 9%-10% of individuals aged 40+ globally.
- The disease involves chronic bronchitis/emphysema, airflow obstruction, and can lead to cor pulmonale and respiratory failure.
- Immune-metabolic dysfunction, including mitochondrial injury and excessive ROS, disrupts energy-sensing pathways and weakens mitochondrial biogenesis.
- NF-κB-driven senescence and NLRP3 inflammasome activation form a reinforcing circuit, promoting immune cell dysfunction.
- Persistent inflammation and metabolic instability contribute to airway remodeling and lung function decline.
- Potential interventions include composite biomarker panels and multi-target therapies to address immune-metabolic disturbances.