Clinical strategies for lymphoma management: Recommendations from the Bridging the Gaps in Leukemia, Lymphoma, and Multiple Myeloma Consensus Conference 2025 - PubMed
4 hours ago
- #Consensus Recommendations
- #CAR T-cell Therapy
- #Lymphoma Management
- Multidisciplinary experts developed consensus recommendations for lymphoma management at the 2025 Bridging the Gaps Consensus Conference.
- For mantle cell lymphoma (MCL), key strategies include screening for high-risk features, using BOVen regimen for TP53-aberrant cases, and integrating CAR T-cell therapy for refractory patients.
- For chronic lymphocytic leukemia (CLL), recommendations include time-limited therapies for younger patients and a 'watch and wait' approach for asymptomatic ones.
- For diffuse large B-cell lymphoma (DLBCL), the article highlights challenges in treatment sequencing and the role of circulating tumor DNA/minimal residual disease testing.
- The consensus emphasizes tailored therapeutic strategies based on recent advancements and ongoing research to improve patient outcomes.
- The modified Delphi process was used to address gaps in clinical practice where high-level evidence is lacking.