Hsp90 buffers behavioral variability by regulating Pdf transcription in clock neurons of Drosophila melanogaster - PubMed
4 days ago
- #Drosophila melanogaster
- #circadian rhythms
- #HSP90
- HSP90 (HSP83 in Drosophila) buffers behavioral variability by regulating Pdf transcription in clock neurons.
- HSP83 is crucial for efficient transcription of the Pigment Dispersing Factor (PDF) neuropeptide gene and its accumulation in clock neurons.
- Hsp83 mutants affect synchronized oscillations of the clock protein PERIOD (PER) similarly to flies lacking PDF.
- The study suggests HSP83's role in restricting temporal niche extension under stressful conditions.
- Findings provide a mechanistic explanation for HSP83's function in regulating behavioral variability.