Integrating multiomic layers to decode psychiatric disease mechanisms - PubMed
3 hours ago
- #genomics
- #multiomics
- #psychiatric disorders
- Psychiatric disorders like schizophrenia, bipolar disorder, and major depression are highly polygenic with risk variants in noncoding regions.
- Multiomic technologies (single-cell transcriptomics, epigenomics, proteomics, spatial profiling) enable integrative analyses linking genetic variation to disease mechanisms.
- Recent advances include single-cell/spatial omics, regulatory element dissection, and computational causal inference frameworks.
- These approaches help transition from genetic variants to mechanisms, aiding biomarker discovery and precision therapies.
- Genomic studies reveal hundreds of risk loci and genetic overlap across psychiatric disorders, emphasizing multiomic integration.