Arginase 1 promotes hepatic lipogenesis by regulating ERK2/PPARγ signaling in a non-canonical manner - PubMed
2 days ago
- #hepatic lipogenesis
- #metabolic disorders
- #ERK2 signaling
- Arginase 1 (Arg1) promotes hepatic lipogenesis by regulating ERK2/PPARγ signaling in a non-canonical manner.
- Mice lacking hepatic Arg1 show reduced lipid accumulation in liver and adipocytes, similar to effects seen with Arg1 inhibitor treatment in obesity models.
- Arg1 competes with RSK2 and Elk1 for binding to ERK2, enhancing ERK2 degradation and upregulating AKT/mTOR/PPARγ and Elk1/c-Fos/PPARγ pathways.
- Peptides disrupting the Arg1-ERK2 interaction improve metabolic profiles in obesity and MASLD models.
- The Arg1-ERK2 interaction is a potential therapeutic target for obesity and related metabolic disorders in male mice.